Liquid and gel formulations are the superior choice because they are chemically and physically compatible with the microscopic environment created by the laser. While laser-created channels are hydrophilic (water-loving), ointments are hydrophobic (water-repelling) and highly viscous; this fundamental mismatch prevents ointments from entering the channels, whereas liquids and gels can flow freely into the skin to deliver medication.
Success in laser-assisted drug delivery is defined by the carrier's ability to physically enter the ablated pore. Because laser micro-channels are hydrophilic, only low-viscosity, aqueous formulations can penetrate effectively, while hydrophobic ointments simply sit on the surface and block delivery.
The Physics of Micro-Channel Interaction
The Nature of Ablated Tissue
Laser ablation creates micron-sized pores, often referred to as micro-channels, in the skin barrier. Crucially, these channels exhibit hydrophilic properties.
This means the interior surfaces of these channels naturally attract water and water-based substances.
Why Liquids and Gels Penetrate
Because liquids and gels are typically water-based, they share an affinity with the hydrophilic micro-channels.
This compatibility allows the formulation to flow smoothly into the pore. The low viscosity of these carriers enables them to fill the interior of the channel completely, bringing the active drug into direct contact with deeper tissue layers.
Why Ointments Fail as Delivery Vehicles
The Barrier of Hydrophobicity
Greasy creams and ointments generally possess hydrophobic properties.
When applied to a hydrophilic laser channel, these formulations are chemically repelled. Instead of being drawn into the pore, the ointment resists entry, significantly hindering the transport of the drug.
The Problem of High Viscosity
Beyond chemical polarity, the physical thickness of the formulation is a major limiting factor. Ointments have high viscosity.
This thickness prevents the substance from squeezing into the micron-sized ablative pores. Consequently, the ointment bridges over the opening of the channel rather than filling it, leaving the active ingredients stranded on the skin's surface.
Understanding the Trade-offs
Diffusion Efficiency
The ultimate goal of laser-assisted delivery is to bypass the skin's outer barrier.
When an ointment prevents channel penetration, the drug must rely on passive diffusion from the surface, which is slow and inefficient. In contrast, gels ensure the drug is physically present deep within the tissue, maximizing diffusion efficiency.
Vehicle Selection Errors
A common pitfall is assuming that a "stronger" or more occlusive ointment will drive better results.
In the context of open laser channels, the physical inability of an ointment to enter the pore negates its potency. You effectively close the door on the delivery pathway you just created with the laser.
Making the Right Choice for Your Goal
To maximize the efficacy of laser-assisted treatments, your formulation choice must be dictated by the physics of the ablated skin.
- If your primary focus is rapid drug absorption: Utilize liquid or gel-based carriers to take advantage of the channel's hydrophilic nature for immediate deep-tissue ingress.
- If your primary focus is preventing treatment failure: Strictly avoid high-viscosity, greasy ointments during the delivery phase, as they will mechanically block the micro-channels.
Match your vehicle's viscosity and polarity to the channel's physiology to ensure the drug reaches its target.
Summary Table:
| Feature | Liquid/Gel Formulations | Ointment Formulations |
|---|---|---|
| Polarity | Hydrophilic (Water-loving) | Hydrophobic (Water-repelling) |
| Viscosity | Low (Flows easily) | High (Thick/Greasy) |
| Penetration | Enters micro-channels effectively | Blocks micro-channel openings |
| Efficiency | Rapid deep-tissue absorption | Slow, inefficient surface diffusion |
Elevate Your Clinic's Precision with BELIS
To achieve superior results in laser-assisted drug delivery, pairing the right formulations with industry-leading technology is essential. BELIS specializes in professional-grade medical aesthetic equipment designed exclusively for clinics and premium salons.
Our advanced CO2 Fractional, Nd:YAG, and Pico laser systems create the precise micro-channels needed for optimal drug absorption. Beyond laser technology, our portfolio includes HIFU, Microneedle RF, Diode Hair Removal, and comprehensive body sculpting solutions like EMSlim and Cryolipolysis. We also offer specialized care devices, including Hydrafacial systems and skin testers, to support your entire treatment workflow.
Ready to upgrade your practice with high-performance equipment and expert insights? Contact us today to discuss your needs and see how BELIS can bring unmatched value to your business.
References
- A. Alegre‐Sánchez, P. Boixeda. Laser-Assisted Drug Delivery. DOI: 10.1016/j.adengl.2018.10.012
This article is also based on technical information from Belislaser Knowledge Base .
Related Products
- RF Microneedling Machine Micro Needle Radio Frequency Machine
- Cryolipolysis Fat Freezing Cavitation Lipo Laser Machine
- 7D 12D 4D HIFU Machine Device
People Also Ask
- Who is considered an ideal candidate for RF microneedling? Discover Your Suitability for Skin Transformation
- What is the role of Radiofrequency (RF) devices with PRP for striae distensae? Boost Synergy for Stretch Mark Repair
- What is the key physical function of Radiofrequency Microneedling for hyperhidrosis? Achieve Permanent Sweat Reduction
- Why is the application of saline-soaked gauze and ice packs recommended after microneedling? Optimize Post-Treatment Care
- Why combine subcision and lasers for rolling scars? Unlock Superior Results with Dual-Action Remodeling
