How Is Cryolipolysis Applied To The Abdomen And What Are The Expected Results? Achieve 20-25% Permanent Fat Reduction

Learn how abdominal cryolipolysis targets subcutaneous fat for permanent reduction, typical results timelines, and patient suitability criteria.

What Is The Typical Recovery Time Associated With Laser Lipolysis? Quick Return To Routine And Zero Downtime Tips

Learn about laser lipolysis recovery: enjoy zero downtime, return to work immediately, and understand the 6-8 week timeline for visible results.

How Long Do The Results Of A Fat Freezing Procedure Last? Discover The Longevity And Key To Permanent Body Contouring

Learn why fat freezing results last 6-9 years and how lifestyle choices impact the permanence of cryolipolysis for long-term body sculpting.

How Does Pico Laser Technology Function For Tattoo Removal? Discover The Gold Standard In Ink Clearing Efficiency

Learn how Pico laser's photomechanical shockwaves shatter tattoo ink into microscopic particles for faster, safer, and more effective removal.

How Does Co2 Laser Treatment Affect Acne Scars? Discover The Power Of Dermal Remodeling And Collagen Boost

Learn how CO2 fractional lasers remodel skin structure to eliminate acne scars by triggering deep collagen production and thermal healing.

For Which Skin Types Is The Nd:yag Laser The Most Appropriate Choice? Safe & Effective Solutions For Darker Skin Tones

Learn why the Nd:YAG laser is the safest choice for Fitzpatrick skin types IV-VI. Ideal for hair removal, vascular lesions, and tattoo removal.

What Is The Procedure For Nonablative Skin Resurfacing For Wrinkles And Acne Scars? Achieve Smooth Skin With Nd:yag

Learn how Q-switched Nd:YAG lasers treat wrinkles and acne scars via deep dermal collagen stimulation with zero downtime and 1064 nm precision.

What Is The Timeline Of The Biological Process After Cryolipolysis? Track Your Fat Loss Journey Step-By-Step

Understand the 3-month biological timeline of Cryolipolysis, from initial cell apoptosis to visible fat reduction and permanent body contouring.

What Is The Purpose Of An Intelligent Water Temperature Control System In Laser Equipment? Protect Your Laser Handle

Learn how intelligent water temperature control prevents overheating and protects expensive laser handles from permanent thermal damage.

What Is The Expected Timeline And Permanence Of Results From Cryolipolysis? Get Lasting Body Contouring Success

Learn the timeline for Cryolipolysis results and how to maintain permanent fat reduction through a biological cell elimination process.

For Whom Is Cryolipolysis Not Recommended? Critical Contraindications And Ideal Candidate Selection

Learn who should avoid cryolipolysis, including medical contraindications like cold-sensitivity disorders, pregnancy, and obesity constraints.

What Is The Scientific Principle Of Cryolipolysis? Master The Art Of Fat Freezing For Body Contouring

Learn how cryolipolysis uses controlled cooling to selectively destroy fat cells via apoptosis without damaging skin or surrounding tissues.

What Role Does An Integrated Contact Cooling Handpiece Play? Maximize Safety & Efficacy In Nd:yag Laser Treatments

Learn how contact cooling handpieces protect the skin, reduce PIH, and allow higher energy for effective Nd:YAG laser hair removal treatments.

What Is The Technical Function Of The Micro-Ablative Fractional Co2 Laser System For Vva? Revitalize Vaginal Health

Learn how Fractional CO2 Laser energy stimulates collagen, triggers tissue remodeling, and restores vaginal health to treat atrophy effectively.

What Is The Primary Objective Of A 0% Overlap Setting In Fractional Laser Ablation? Master Safe Thermal Management

Learn how 0% overlap prevents thermal stacking, reduces burn risks, and ensures uniform results in fractional laser skin ablation procedures.

What Role Does A High-Precision Digital Hair Follicle Detection System Play In Assessing Hair Diameter? Expert Guide

Discover how digital hair detection systems provide micron-level accuracy for mapping donor areas and ensuring natural hair restoration results.

Why Is The Application Of A 2-3Mm Layer Of Medical Cooling Gel Required Before Laser Hair Removal? Ensure Safety & Efficacy

Learn why medical cooling gel is essential for laser hair removal, providing optical coupling and thermal protection for safe, effective results.

What Is The Primary Function Of Professional-Grade Fractional Co2 Lasers? Mastering Combined Aesthetic Treatments

Learn how Fractional CO2 lasers use thermal ablation to create channels for collagen regeneration and enhanced transdermal delivery of bioactives.

How Does Cryolipolysis Reduce Fat In Pcos Patients? Effective Body Contouring For Metabolic Resistance

Learn how Cryolipolysis uses cold-induced apoptosis to bypass metabolic hurdles in PCOS patients for permanent, non-invasive fat reduction.

What Role Does The Co2 Fractional Laser Play In The Treatment Of Acne Scars? Advanced Resurfacing For Flawless Skin

Learn how CO2 fractional lasers ablate scar tissue and stimulate collagen remodeling to achieve 50-81% improvement in atrophic acne scars.

Why Is The 532 Nm Wavelength Ideal For Freckles? Master Precision For Surface Pigment Removal

Learn why the 532 nm wavelength is the gold standard for treating superficial lesions like freckles through targeted melanin absorption.

Why Is Energy Density Calibration Essential For Lllt? Ensure Precision And Safety In Laser Therapy

Learn why energy density (fluence) calibration is critical for LLLT efficacy, safety, and adherence to the Reciprocity Law in clinical settings.

What Are The Technical Advantages Of Incorporating A 1570 Nm Non-Ablative Laser? Unlock Dual-Mode Synergy & Safety

Learn how the 1570 nm laser enhances dual-mode platforms by targeting the dermis, reducing PIH risk, and accelerating recovery for clinic patients.

How Does Fractional Co2 Laser Technology Differ From Fully Ablative Mode In Onychomycosis? Maximize Treatment Efficacy

Understand the difference between fractional and fully ablative CO2 lasers for Onychomycosis, from drug delivery to surface vaporization.

How Does The Spray Duration Of Cold Spray Cooling Impact Thermal Protection? Optimize Safety In Laser Hair Removal

Learn how CSC spray duration controls epidermal cooling and creates a thermal buffer to prevent burns during laser treatments.

What Role Does The Hand-Held Forked Probe Play? Enhance Fractional Laser Precision & Safety

Learn how the Hand-held Forked Probe stabilizes fractional laser treatments by maintaining focal distance and protecting healthy tissue.

What Is The Primary Purpose Of Using An Led Phototherapy System Post-Co2 Laser? Enhance Recovery & Prevent Pih

Discover how LED phototherapy accelerates barrier repair and prevents post-inflammatory hyperpigmentation after CO2 fractional laser treatments.

How Does The Treatment Process Of Fractional Picosecond Lasers Differ From Ablative Fractional Lasers For Acne Scars?

Explore the differences between fractional picosecond (LIOB) and ablative fractional (CO2) lasers for treating atrophic acne scars and recovery.

How Are Professional Hair Follicle Microscopic Scanners Used To Evaluate The Effectiveness Of Laser Hair Removal?

Discover how professional hair scanners provide quantitative data on density and diameter to validate laser hair removal results and ensure safety.

What Role Does A Professional-Grade Fractional Co2 Laser System Play In The Treatment Of Skin Photoaging? Advanced Guide

Learn how professional fractional CO2 lasers reverse photoaging through Micro-Thermal Zones, collagen regeneration, and rapid healing technology.

What Are The Primary Functions Of Conductive Transparent Gel? Boost Treatment Safety & Results With Optimal Coupling

Learn why conductive gel is essential for laser hair removal, from optimizing light penetration to protecting the skin with thermal cooling.

What Is The Function Of A Single-Mode Pulsed Periodic Co2 Laser? Master Precision In Tissue Ablation

Learn how single-mode pulsed CO2 lasers achieve high-precision tissue ablation with minimal thermal damage and superior surgical control.

What Is The Necessity Of An Automatic Lockout Protection Mechanism In Long-Pulse Nd:yag Laser Systems? Expert Safety Guide

Learn how automatic lockout mechanisms in Nd:YAG lasers prevent thermal injury by monitoring epidermal temperatures in real-time during skin remodeling.

What Are The Technical Advantages Of Er:yag 2940Nm Lasers For Eyelid Resurfacing? Precision Over Traditional Co2

Discover why Er:YAG 2940nm lasers offer superior precision, faster recovery, and lower risk for delicate eyelid resurfacing compared to CO2 lasers.

What Is The Role Of Fractional Ablative Co2 Laser In The Treatment Of Necrobiosis Lipoidica? Advance Skin Remodeling

Learn how Fractional CO2 Laser treats Necrobiosis Lipoidica by inducing collagen remodeling and fibroblast activation for smoother skin.

What Is The Primary Role Of Fractional Co2 Laser Systems In Treating Acne Scars? Unlock Superior Skin Resurfacing

Learn how Fractional CO2 Lasers use MTZs to remodel collagen and treat atrophic acne scars through advanced fractional photothermolysis.

How Does A Microlens Array Achieve The Fractional Ablation Effect? Advanced Laser Optics For Rapid Skin Regeneration

Learn how microlens arrays split laser beams into precise matrices to create Microscopic Ablation Zones for deep dermal repair and fast healing.

What Risks Are Associated With Using Medical-Grade Lasers On Cosmetic Tattoos? Prevent Paradoxical Darkening Today

Learn why iron oxide and titanium dioxide in cosmetic tattoos can turn black when treated with lasers and how to manage these clinical risks.

What Are The Technical Advantages Of Fractional Photothermolysis? The Safer Way To Skin Resurfacing

Learn how fractional photothermolysis offers faster healing and lower risks compared to traditional ablative lasers through microscopic targeting.

What Role Does The Long-Pulse Nd:yag Laser Play In Deep Vascular Malformations? Precision Solutions For Deep Lesions

Learn how the 1064nm Long-pulse Nd:YAG laser penetrates deep tissue to coagulate complex vascular malformations and venous lesions effectively.

What Are The Clinical Advantages Of The Fractional Scanning Output Mode? Maximize Safety & Speed Healing

Discover why fractional scanning mode is superior to traditional ablation, offering faster re-epithelialization and reduced risk of complications.

What Are The Specific Applications Of The Frequency-Doubled Nd:yag Laser (Ktp Laser)? Treat Surface Pigment Effectively

Discover how the 532nm KTP laser targets freckles, age spots, and sun damage with precision using selective photothermolysis.

How Is The 10-Cm Visual Analog Scale (Vas) Used For Laser Treatment Efficacy? Quantify Pain And Healing Progress

Learn how the 10-cm VAS objectively measures pain, dryness, and itching to track the long-term efficacy of fractional laser treatments.

How Do Fractional Co2 Laser Energy Settings Influence Vitamin Delivery? Optimize Absorption And Clinical Results.

Learn how pulse energy and energy density settings in Fractional CO2 Lasers create channels to enhance intradermal vitamin delivery for skin repair.

What Are The Advantages Of Using Professional Laser Systems For Treating Benign Eyelid Lesions? Achieving Peak Precision

Learn why professional CO2 and Picosecond lasers are the gold standard for removing eyelid lesions like seborrheic keratosis with minimal scarring.

What Are The Safety Advantages Of Fractional Co2 Lasers For Darier Disease? Enhanced Recovery & Minimized Risk

Discover why Fractional CO2 lasers are safer than traditional ablative lasers, featuring skin bridges for faster healing and reduced scarring.

How Does The Pulsed Mode Of Medical Co2 Lasers Enhance Sui Treatment Safety? Advanced Thermal Control For Clinics

Learn how Pulsed Mode in CO2 lasers prevents burns and carbonization during SUI treatments by utilizing thermal relaxation for maximum safety.

How Does The Thermal Effect Generated By Fractional Co2 Laser Systems Improve Skin Texture? Transform Scars And Plaques

Learn how Fractional CO2 Laser thermal energy stimulates fibroblasts and collagen remodeling to soften indurated plaques and improve skin texture.

What Are The Technical Advantages Of Using A Large Laser Spot Diameter For Deep Vascular Lesions? Maximize Penetration

Learn how laser spot diameters ≥5mm reduce optical scattering and preserve energy density for effective treatment of deep-seated vascular lesions.

What Are The Core Technical Advantages Of Fractional Co2 Laser (Flt)? Transform Hypertrophic Burn Scar Treatment

Learn how Fractional CO2 Laser technology uses micro-thermal zones and structural remodeling to treat hypertrophic scars and reorganize collagen.

What Function Does A Dynamic Cooling Device Serve? Maximize Laser Hair Removal Safety And Efficacy

Learn how Dynamic Cooling Devices (DCD) protect the epidermis, allow for higher laser energy, and improve patient comfort during hair removal.

What Is The Primary Function Of The Long-Pulsed 1064Nm Nd:yag Laser In Akn? Stop Inflammation & Destroy Hair Follicles

Learn how the 1064nm Nd:YAG laser treats Acne Keloidalis Nuchae (AKN) by targeting deep follicles and halting granulomatous immune reactions safely.

How Do High-Precision Laser Systems Effectively Remove Tattoos? Discover The Power Of Photoacoustic Technology

Learn how Q-switched and Picosecond lasers use photoacoustic shockwaves to shatter tattoo ink for safe, effective removal with minimal scarring.

Why Is A Sapphire Contact Cooling Handpiece Essential For Laser Hair Removal On Patients With Fragile Skin?

Discover why sapphire contact cooling is crucial for protecting fragile skin during laser hair removal by providing active thermal protection.

Why Are Specific Pulse Modes Used In Co2 Laser Devices For Gsm? Master The Science Of Vaginal Health

Learn how dual-phase CO2 laser pulse modes optimize GSM treatment by balancing surface ablation with deep submucosal collagen regeneration.

How Do The Power Settings And Pulse Energy Of A Fractional Co2 Laser Influence Scar Repair? Optimize Your Clinical Results

Learn how the synergy between power and pulse energy in Fractional CO2 Lasers drives deep tissue remodeling while ensuring patient safety.

What Are The Advantages Of A 64 Micro-Needle Rf Head For Vaginal Treatment? Boost Clinical Efficiency And Precision

Discover how 64-electrode matrix technology optimizes vaginal mucosa treatment through multi-point ablation and precision tissue remodeling.

Why Is The Nd:yag Laser Recommended For Facial Warts? Achieve Rapid Clearance With Superior Aesthetic Outcomes

Discover why Nd:YAG laser is the top mono-therapy for facial warts, offering deep penetration, rapid clearance, and zero permanent tissue damage.

What Role Do 2940Nm Erbium Laser Systems Play In Cosmetic Permeability And Safety Research? Advanced Research Insights

Explore how 2940nm Erbium lasers enhance transdermal absorption and simulate extreme safety conditions for advanced cosmetic and toxicity research.

How Do Non-Ablative Fractional Lasers Balance Efficacy And Safety In Skin Rejuvenation? Achieve High-Reward Results

Learn how Erbium Glass lasers use Micro-Thermal Zones to stimulate collagen and treat photodamage with zero downtime and maximum safety.

How Does The Fractional Er:yag Laser Differ From The Co2 Laser? Compare Performance For Scar Repair & Recovery

Compare Er:YAG vs. CO2 lasers for scar repair. Learn about cold ablation, water absorption, and how to choose the right laser for skin resurfacing.

What Are The Advantages Of Using A Composite Structure (Yag/Nd:yag/Yag) Crystal Rod? Maximize Your Laser Power & Quality

Learn how YAG/Nd:YAG/YAG composite rods optimize thermal management, reduce lensing, and prevent crystal damage in high-power laser systems.

How Does The Scio Guide 1064Nm Nd:yag Laser Treatment? Optimize Your Onychomycosis Clinical Outcomes

Learn how the SCIO index predicts long-pulse 1064nm Nd:YAG laser efficacy and guides customized treatment plans for onychomycosis severity.

How Does The Micro-Ablative Fractional Co2 Laser System Function In The Treatment Of Gsm? Restore Vaginal Health Safely

Learn how fractional CO2 laser technology reverses vaginal atrophy by stimulating collagen, improving pH, and restoring tissue elasticity for GSM.

What Is The Clinical Purpose Of Applying Medical-Grade Ice Packs After A Picosecond Laser? Prevent Pih & Reduce Redness

Learn why medical-grade cooling is essential after Picosecond Nd:YAG laser to prevent PIH, reduce edema, and protect healthy skin tissue.

What Is The Primary Function Of The Long-Pulse 1064Nm Nd:yag Laser In Hs And Pns Treatment? Stop Follicular Recurrence

Learn how the Long-pulse 1064nm Nd:YAG laser targets follicular occlusion and ensures deep tissue penetration for effective HS and PNS treatment.

What Are The Advantages Of Rf Scalpels Or Co2 Lasers For Blepharoplasty? Modern Tech Vs. Traditional Cold Scalpels

Discover why RF scalpels and CO2 lasers outperform cold scalpels in blepharoplasty through superior hemostasis, less bruising, and faster recovery.

Why Is A Customized Pigment Fading Percentage Photographic Scale Utilized? Standardizing Laser Tattoo Removal Success

Learn how standardized photographic scales eliminate bias and provide objective data for measuring laser tattoo removal effectiveness.

How Do Co2 Fractional And Er:yag Lasers Differ In Thermal Coagulation Zones? Choose The Best Tech For Your Clinic

Compare CO2 and Er:YAG lasers: understand how water absorption affects thermal coagulation zones, recovery time, and skin tightening results.

What Role Do High-Resolution Clinical Digital Photographs Play In The Sequential Efficacy Assessment Of Hirsutism?

Discover how clinical photography provides objective mVAS scoring, hair density tracking, and standardized visual evidence for hirsutism treatments.

Why Is The Combination Of Medical Laser Systems And Topical Preparations Necessary For Treating Pathological Scars?

Learn how medical lasers and topical agents work together to maximize scar healing through deep drug delivery and moisture retention.

Why Use Collagen-Stimulating Lasers For Depressed Scars? Unlock Structural Repair With Nd:yag Technology

Discover how advanced laser equipment repairs depressed acne scars by stimulating endogenous collagen for deep structural restoration.

How Do Ice Packs And Cold Gels Assist In Laser Hair Removal? Master Thermal Management For Optimal Safety

Learn how ice packs and cold gels act as thermal regulators and optical enhancers to prevent burns and improve laser hair removal efficiency.

What Role Do Professional Dermoscopy Or Trichoscopy Devices Play In The Diagnosis Of Aga? Enhance Hair Loss Assessment

Learn how professional trichoscopy devices enable early AGA diagnosis through microscopic indicators like hair diameter diversity and peripilar signs.

Why Is The Control Of Pulse Width Modulation (Pwm) Parameters Critical For The Safety And Efficacy Of Laser Equipment?

Master PWM control to ensure precise laser energy delivery, prevent thermal injury, and optimize clinical results in medical aesthetic treatments.

Why Is The Selection Of Treatment Timing Critical To The Performance Of Co2 Laser Equipment For Burn Scar Therapy?

Learn why timing is essential for CO2 laser scar therapy to minimize adverse reactions, reduce pain, and optimize collagen remodeling results.

What Is The Heat Dissipation Function Of High-Transparency Aqueous Gel? Enhancing Safety In Laser Hair Removal

Learn how high-transparency aqueous gel acts as a passive heat sink to prevent burns and improve comfort during laser hair removal treatments.

How Does The Low-Power Freehand Mode Of A Co2 Laser Enhance Ear Keloid Surgery? Precision Sculpting Explained

Learn how the 0.3-2.5W low-power mode of a CO2 laser ensures precise ear keloid removal while protecting delicate cartilage and reducing necrosis.

Which Technical Challenges Are Addressed By The Application Of Forced Air Cooling Systems? Improve Laser Safety

Learn how forced air cooling manages thermal diffusion and pain during high-energy fractional laser treatments for safer, more effective results.

What Is The Recommended Practice For Adding Solutions To An Aqua Hydra Facial Machine? Expert Hygiene & Safety Tips

Learn the best practices for filling aqua hydra facial machines to ensure hygiene, prevent contamination, and optimize treatment results.

How Does Cryolipolysis Eliminate Unwanted Bulges Of Fat? Science-Backed Fat Removal With Cryo Sculpting

Learn how Cryolipolysis uses apoptosis and precise cooling to permanently eliminate stubborn fat bulges for non-surgical body contouring.

What Is The Expected Fat Reduction Outcome Of A Cryolipolysis Treatment? Achieve Targeted 25% Fat Loss

Learn about Cryolipolysis fat reduction outcomes, from the standard 20-25% reduction to the 3-6 month timeline for maximum body contouring results.

What Are The Potential Complications After A Fractional Laser Treatment? Expert Safety And Recovery Guide

Learn to manage fractional laser complications like hyperpigmentation and infection while distinguishing them from normal recovery side effects.

How Quickly Are Results From Cryolipolysis Visible? Timeline For Body Sculpting Transformation

Learn when to expect cryolipolysis results, from the first signs at 3 weeks to optimal contouring at 3 months post-treatment.

What Are The Serious Side Effects Associated With Cryolipolysis? Safety Risks & Professional Complication Analysis

Learn about serious cryolipolysis risks like PAH and motor neuropathy. Distinguish between mild reactions and severe complications for safer results.

How Does The Q-Switched Laser Work? Unlock Advanced Pigment Removal And Skin Rejuvenation Technology

Learn the mechanics of Q-Switched lasers: how high-energy pulses shatter pigment and stimulate collagen for clear, youthful skin.

How Do Q-Switched Lasers Function In The Treatment Of Onychomycosis? Advanced Solutions For Fungal Nail Clearance

Learn how Q-switched lasers use nanosecond pulses to disintegrate fungal cells, stimulate nail growth, and provide a painless treatment experience.

What Skin Conditions Can Laser Resurfacing Treat? Discover 10+ Benefits For Clinical Rejuvenation

Learn how laser resurfacing treats wrinkles, acne scars, pigmentation, and medical growths like actinic keratosis for flawless skin.

How Can Laser Lipolysis Be Combined With Other Treatment Modalities? Maximize Results With Synergistic Body Sculpting

Learn how combining laser lipolysis with CO2 lasers and liposuction enhances skin tightening, collagen production, and body contouring results.

What Are The Technical Advantages Of Fractional Technology In Co2 Laser Treatments? Safer, Faster Healing Solutions

Discover why fractional CO2 laser technology offers faster healing and lower risks than traditional ablation through innovative skin bridge tech.

Why Is Co2 Fractional Laser Preferred For Hypertrophic Scars? The Gold Standard For Advanced Skin Resurfacing

Learn why the 10,600nm CO2 Fractional Laser is the top choice for hypertrophic scar treatment through ablation and deep collagen remodeling.

What Is The Mechanism Of Action For The Long-Pulsed Nd:yag Laser? Effective Onychomycosis Treatment Via 1064Nm Heat

Learn how the 1064nm Nd:YAG laser uses photothermal energy to penetrate nail plates and destroy fungal spores without damaging healthy tissue.

How Does A Medical-Grade Fractional Co2 Laser System Achieve The Remodeling Of Atrophic Scars? Proven Skin Regeneration

Learn how Fractional CO2 Lasers use 10,600 nm wavelengths and MTZs to stimulate collagen, fill atrophic scars, and achieve dermal remodeling.

What Is The Function Of Cryolipolysis Technology? Science-Backed Fat Reduction For Body Sculpting

Understand how cryolipolysis uses controlled cooling and apoptosis to selectively eliminate fat cells for non-invasive body contouring.

What Is The Physical Significance Of The Pulse Delay In Nd:yag Laser Vascular Treatments? Optimize Results & Safety

Understand how pulse delay manages Thermal Relaxation Time (TRT) to protect skin while effectively treating vascular lesions with Nd:YAG lasers.

How Does A Professional Q-Switched Alexandrite Laser Treat Becker’s Nevus? Precision Pigment Removal Explained

Learn how Q-switched Alexandrite lasers use selective photothermolysis to shatter melanin and treat deep pigmented lesions like Becker’s nevus.

What Advantages Do Metal Eye Shields Offer Over External Laser Goggles During High-Risk Eyebrow Hair Removal?

Discover why metal eye shields are the only safe choice for eyebrow laser hair removal, offering impenetrable protection that external goggles lack.

What Is The Primary Mechanism Of Action For Micro-Ablative Co2 Fractional Laser? Restore Tissue Health & Elasticity

Learn how CO2 fractional laser technology uses controlled thermal energy to stimulate collagen and treat vaginal atrophy effectively.

What Advantages Does Pulse Stacking Technology Offer When Using Fractional Lasers To Treat Deep Scars? Elevate Safety.

Learn how pulse stacking in fractional lasers enables deeper scar penetration with minimal thermal damage and faster healing for patients.

What Is The Technological Mechanism Behind Combining Fractional Lasers With Microneedle Rf? Boost Healing Efficiency

Learn how dual-layer heating from fractional lasers and Microneedle RF creates a synergistic effect for 40% faster recovery and deep skin remodeling.